Céline Harmanus

The paper characterizes a non-toxigenic C. difficile strain, L-NTCD03, showing antimicrobial resistance and non-toxicity, suggesting its potential as a live biotherapeutic.

This paper describes a GMP-compliant process for producing C. difficile spores for use in controlled human infection models.

This study compares antimicrobial susceptibility testing of C. difficile across three media and three drugs, finding medium-dependent MIC differences and recommending FAA-HB for consistency.

The paper compares core genome MLST (cgMLST) with CE-PCR ribotyping and SNP analysis for C. difficile typing, finding cgMLST offers better discrimination but may require adjusted thresholds for outbreak detection.