Capillary-based Subcellular Sampling Uncovers the Stress Granule Proteome in Single Cells
Claire Davison, Nicolas Locker, Mariana Marques, Sam Kelly, Emily Relton, Tanavi Sharma, Emily Fraser, Pedro Aragon-Fernandez, Erwin M. Schoof, Mia Petersen, Jordan Pascoe, Kathryn Susan Lilley, Sneha M. Pinto, Matt Spick, Melanie Jane Bailey
The paper introduces a capillary-based subcellular sampling method combined with LC-MS to analyze stress granule proteomes in single cells, identifying 405 high-confidence proteins with minimal cytosolic contamination.
bioRxiv · May 13, 2026 · PreprintCell Biology