Nicolas Locker

Capillary-based Subcellular Sampling Uncovers the Stress Granule Proteome in Single Cells

The paper introduces a capillary-based subcellular sampling method combined with LC-MS to analyze stress granule proteomes in single cells, identifying 405 high-confidence proteins with minimal cytosolic contamination.

Compositional analysis of yellow fever virus induced stress granules reveals a functional connection to mitochondrial homeostasis

This study investigates YFV-induced stress granules, revealing their enrichment in mitochondrial proteins and their role in mitochondrial dysfunction during infection.

The assembly of stress granule-like foci during foot-and-mouth disease virus infection is uncoupled from activation of cellular intrinsic antiviral signalling

This study shows that stress granule formation during FMDV infection is independent of innate immune activation, and that preventing their disassembly reduces viral replication.

The Batten disease protein CLN3 is important for stress granules dynamics and translational activity.

This study shows that CLN3 deficiency disrupts stress granule dynamics and translation, linking it to neurodegenerative disease mechanisms.