Simvastatin attenuates disease phenotypes in human induced pluripotent stem cell models of familial Parkinson's disease through RhoA inhibition
Sissel Ida Schmidt, Justyna Okarmus, Matias Ryding, Ida Keller Skousen, Nicolaj Frederik Broner Jensen, Emil Birch Christensen, Lucas Seidelin Winkelmann, Alice Dupont Juhl, Miamaja Klaebel, Morten Blaabjerg, Kristine Freude, Daniel Wüstner, Richard Wade‐Martins, Brent James Ryan, Morten Meyer
This study shows simvastatin reduces PD-related phenotypes in iPSC-derived neurons by inhibiting RhoA, with RhoA activity varying across PD subtypes.
bioRxiv · Aug 31, 2026 · PreprintNeuroscience