Morten Meyer

Simvastatin attenuates disease phenotypes in human induced pluripotent stem cell models of familial Parkinson's disease through RhoA inhibition

This study shows simvastatin reduces PD-related phenotypes in iPSC-derived neurons by inhibiting RhoA, with RhoA activity varying across PD subtypes.

A novel post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson's disease GBA-N370S dopamine neurons

This study uses a novel proteomics platform to identify PTM dysregulation in GBA-N370S PD neurons, revealing impaired neuritogenesis and a role for tau.

Golgi Fragmentation - One of the Earliest Organelle Phenotypes in Alzheimer's Disease Neurons

The paper identifies Golgi fragmentation as an early AD phenotype in neurons using stem cell and mouse models, showing its link to SORL1 variants and glycosylation changes.

Lipotype acquisition during neural development in vivo is not recapitulated in stem cell-derived neurons

This study shows that mouse brain lipotypes develop in two stages, with cholesterol increasing postnatally, and that stem cell-derived neurons do not fully recapitulate this lipotype.

USP30 inhibition induces mitophagy and reduces oxidative stress in parkin-deficient and CCCP-stressed human iPSC-derived neurons

The paper shows USP30 inhibition enhances mitophagy and reduces oxidative stress in parkin-deficient neurons, with non-dopaminergic neurons being the main受益者.

Polo-like kinase 2 inhibition reduces serine-129 phosphorylation of physiological nuclear alpha-synuclein but not of the aggregated alpha-synuclein

This study shows that PLK2 inhibition reduces soluble nuclear pS129 levels but not aggregated pS129 in synucleinopathy models.

Identification of bioactive metabolites in human iPSC-derived dopaminergic neurons with PARK2 mutation: altered mitochondrial and energy metabolism.

This study identifies altered mitochondrial and energy metabolism in PARK2 mutant human iPSC-derived dopaminergic neurons through metabolomic analysis.

Investigation of anti-IgLON5-induced neurodegenerative changes in human neurons

This study shows that anti-IgLON5 antibodies cause functional and neurodegenerative changes in human neurons, leading to cell death, supporting their role in the disease.

Lysosomal perturbations in dopaminergic neurons derived from induced pluripotent stem cells with PARK2 mutation

This study investigates lysosomal alterations in PARK2 knockout dopaminergic neurons derived from iPSCs, revealing links between parkin deficiency and lysosomal dysfunction in Parkinson's disease.