Sissel Ida Schmidt

This study shows simvastatin reduces PD-related phenotypes in iPSC-derived neurons by inhibiting RhoA, with RhoA activity varying across PD subtypes.

This study uses forebrain organoids to show that schizophrenia involves sex-specific protein-state dysregulation, with changes in post-translational modifications and proteomic pathways rather than transcript levels.

This study uses patient-derived organoids to identify synaptic protein and phospho-regulatory deficits in schizophrenia.

This study compares guided and unguided forebrain organoids using multi-omic analyses, revealing differences in cellular composition, metabolic profiles, and post-translational modifications.

This study uses a novel proteomics platform to identify PTM dysregulation in GBA-N370S PD neurons, revealing impaired neuritogenesis and a role for tau.

This study shows that PLK2 inhibition reduces soluble nuclear pS129 levels but not aggregated pS129 in synucleinopathy models.

This study identifies altered mitochondrial and energy metabolism in PARK2 mutant human iPSC-derived dopaminergic neurons through metabolomic analysis.

This study investigates lysosomal alterations in PARK2 knockout dopaminergic neurons derived from iPSCs, revealing links between parkin deficiency and lysosomal dysfunction in Parkinson's disease.