Invigorating human MSCs for transplantation therapy via Nrf2/DKK1 co- stimulation in a mice acute-on-chronic liver failure model
Feng Chen, Zhaodi Che, Yingxia Liu, Pingping Luo, Xiao Lu, Yali Song, Cunchuan Wang, Zhiyong Dong, Mianhuan Li, George Lim Tipoe, Dongqing Wu, Min Yang, Yi Lv, Fei Wang, Hua Wang, Jia Xiao
This study shows that co-stimulating Nrf2 and DKK1 in human MSCs improves their therapeutic efficacy in a mouse ACLF model by enhancing anti-inflammatory and regenerative effects.
bioRxiv · May 29, 2022 · PreprintMolecular Biology