Closing and opening of the RNA polymerase trigger loop
Abhishek Mazumder, Miaoxin Lin, Achillefs N. Kapanidis, Richard H. Ebright
The paper uses single-molecule fluorescence resonance energy transfer to study RNA polymerase trigger loop dynamics, showing it closes and opens on the millisecond timescale and functions as a checkpoint for NTP identity and inhibitor target.
Proceedings of the National Academy of Sciences · Jun 22, 2020Peer-reviewedMolecular Biology