CDH1 loss remodels gene expression and lineage identity in human mammary epithelial cells
Maggie Musick, Chinasa A Ufondu, Carmen E. Rowland, Micaela E. Brown, Joseph L. Sottnik, Madeleine T. Shackleford, Camryn S. Nesiba, Etienne P. Danis, Andrew E. Goodspeed, Richard Zera, Arthur T. Johnson, Kathryn L. Schwertfeger, Andy Nelson, Julie Hanson Ostrander, Matthew J. Sikora
This study shows that CDH1 loss in human mammary epithelial cells remodels gene expression and lineage identity toward a luminal progenitor-like state, contributing to ILC oncogenesis.
PLoS Genetics · Oct 27, 2026Peer-reviewedCancer Biology