Andy Nelson

CDH1 loss remodels gene expression and lineage identity in human mammary epithelial cells

This study shows that CDH1 loss in human mammary epithelial cells remodels gene expression and lineage identity toward a luminal progenitor-like state, contributing to ILC oncogenesis.

Tumor Cells Enriched for Interferon and Inflammatory Programs Pre-Exist in High Grade Serous Ovarian Cancer and are Proportionately Significantly Increased Post Chemotherapy

The paper identifies pre-existing tumor cells with interferon and inflammatory programs in HGSOC that increase after chemotherapy, suggesting a therapeutic window for intervention.

A Rapid, Cost-Effective Tailed Amplicon Method for Sequencing SARS-CoV-2

This paper introduces a low-cost, streamlined amplicon-based method for SARS-CoV-2 sequencing that is comparable to existing methods in accuracy and scalability.

RAS Internal Tandem Duplication Disrupts GAP-binding to Activate Oncogenic Signaling

The paper identifies a novel NRAS internal tandem duplication in colorectal cancer that disrupts GAP-binding, leading to sustained RAS activation and oncogenic signaling.