Partitioning heritability using single-cell multi-omics identifies a novel macrophage subpopulation conveying genetic risks of coronary artery disease.
Jiahao Jiang, Thomas K. Hiron, Thomas A. Agbaedeng, Yashaswat Malhotra, Edward Drydale, James M. Bancroft, Esther Ng, Michael E. Reschen, Lucy J. Davison, Christopher A. O’Callaghan
The paper identifies a novel macrophage subpopulation, lipid-handling macrophages, that is enriched with CAD genetic risk and shows how a risk variant affects FDX1 through AP-1 and C/EBP-beta recruitment.
bioRxiv · Sep 14, 2023 · PreprintGenetics