A combinatorial pre-mRNP retention factor network couples nuclear speckle architecture to splicing quality control
Kerstin Dörner, Kai Kurth, Nicole Beuret, Nikolaus Beer, Michael K. Jones, Karen Davey, Lea Stadelmann, Dominik Huegli, Alexia Ferrand, Giulia Basile, Seraphine Luescher, Jernej Ule, Franka Voigt, Maria Hondele
The paper identifies a network of RNA-binding proteins that retain pre-mRNPs in nuclear speckles, linking splicing status to nuclear retention and speckle organization.
bioRxiv · Sep 29, 2026 · PreprintCell Biology