Alexia Ferrand

The paper identifies a network of RNA-binding proteins that retain pre-mRNPs in nuclear speckles, linking splicing status to nuclear retention and speckle organization.

SPEx enables compartment-resolved proteomics by expanding cells, microdissecting regions of interest, and analyzing them with mass spectrometry, revealing novel organelle components.

The paper identifies a nucleolus-like condensate in E. coli that forms during cold adaptation to enhance ribosome biogenesis.

The paper maps Staphylococcus aureus microgeography in human tissue using AI-guided imaging and finds antibiotic failure is linked to intracellular bacterial persistence and metabolic constraints.