Franka Voigt

A combinatorial pre-mRNP retention factor network couples nuclear speckle architecture to splicing quality control

The paper identifies a network of RNA-binding proteins that retain pre-mRNPs in nuclear speckles, linking splicing status to nuclear retention and speckle organization.

Live single-molecule imaging reveals global shifts in mRNA mobility during human stem cell differentiation

The paper tracks mRNA mobility during human stem cell differentiation and finds that mRNA dynamics shift towards constrained patterns as cells acquire identity.

Transcriptional feedback of Erk signaling waves in zebrafish scale regeneration

The paper shows Erk signaling waves in zebrafish scale regeneration induce inhibitor transcript waves and modulate osterix transcription, linking wave dynamics to tissue growth and maturation.

Fbxo42 promotes the degradation of Ataxin-2 granules to trigger terminal Xbp1 signaling

This study shows Fbxo42 promotes degradation of Ataxin-2 granules, enabling Xbp1 translation and triggering cell death during terminal UPR activation.

Single-molecule imaging of mRNA localization and regulation during the integrated stress response

The paper uses single-molecule imaging to study mRNA localization in stress granules and processing bodies during the integrated stress response and finds similar translation and degradation rates for mRNA in these compartments compared to cytosol.