Maria Hondele

This paper introduces a sequential Design of Experiments framework to study multidimensional biomolecular condensation, revealing protein-specific interactions and context-dependent behaviors in RNA-binding condensates.

The paper identifies a network of RNA-binding proteins that retain pre-mRNPs in nuclear speckles, linking splicing status to nuclear retention and speckle organization.

The paper identifies a nucleolus-like condensate in E. coli that forms during cold adaptation to enhance ribosome biogenesis.

This study identifies PAIP1 as a cofactor for mRNA export and shows it couples nuclear to cytoplasmic mRNP remodeling and poly(A) homeostasis, affecting mRNA stability and development.

This study characterizes the pyrenoid structure and molecular components of Chlorella sorokiniana, revealing conserved inorganic carbon delivery machinery and novel proteins involved in pyrenoid assembly and starch tethering.

This study identifies how eLOTUS domains activate Vasa by promoting its RNA and ATP binding through a charged disordered sequence, revealing a localization-dependent regulatory mechanism.

The paper shows that non-translated mRNA levels influence the biophysical properties and composition of processing bodies (PBs) under different stress conditions.

This study shows that varying the number of binding motifs in a disordered protein affects pyrenoid assembly and algal fitness.

This study examines how protein tags affect condensate formation in different contexts and identifies charge as a key factor influencing condensation behavior.

This study identifies LRBA's role in regulating the endosomal-lysosomal pathway by controlling Rab4+ endosome traffic, leading to enlarged endolysosomes in LRBA-deficient patients.

The paper characterizes RNA content in individual phase-separated coacervate microdroplets using high-throughput sequencing and identifies sequence motifs associated with RNA accumulation.

This study reveals that RNA-bound PGC-1α forms liquid-like nuclear condensates to regulate gene expression and transcriptional networks in response to metabolic stimuli.