IgE occupancy and antigen valency cooperate to control FcϵRI aggregation geometry and signaling efficiency
Birgit Linhart, Rachel M. Grattan, Jon Christian L. David, Elton D. Jhamba, Christian Lupinek, Margarete Focke‐Tejkl, Michael L. Paffett, Shayna R. Lucero, Rudolf Valenta, Lydia Tapia, Bruna Jacobson, Bridget Smith Wilson, Diane S. Lidke
This study shows that allergen valency and epitope arrangement influence FcϵRI aggregation and signaling in mast cells.
International Journal of Molecular Sciences · Jul 28, 2026Peer-reviewedImmunology