Withdrawal-induced escalated oxycodone self-administration is mediated by kappa opioid receptor function
Jacques D. Nguyen, Dean Kirson, Michael Q. Steinman, Reesha R. Patel, Sophia Khom, Florence P. Varodayan, David M. Hedges, Christopher S. Oleata, Yanabel Grant, Marisa Roberto, Michael A. Taffe
This study shows that extended oxycodone self-administration in rats leads to escalated drug use and dysregulation of KOR-mediated GABAergic signaling in the CeA, with distinct neuroadaptive effects compared to other drugs.
bioRxiv · Aug 18, 2017 · PreprintNeuroscience