Author

Sophia Khom

Scripps Research InstituteORCID 0000-0003-3567-8973Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:rat· 2 Assay:electronic health records· 1

Frequent Co-Authors

Jacques D. NguyeniD· 2 shared Marisa RobertoiD· 2 shared Michael A. TaffeiD· 2 shared Yanabel Grant· 2 shared Christopher S. Oleata· 1 shared David M. HedgesiD· 1 shared Dean KirsoniD· 1 shared Florence P. VarodayaniD· 1 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Jacques D. NguyenORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintSep 24, 2021

Self-Administration of entactogen psychostimulants dysregulates GABA and Kappa Opioid Receptor signaling in the central nucleus of the amygdala of female Wistar rats

Sophia Khom, Jacques D. Nguyen, Sophia A. Vandewater…·Michael A. Taffe

This study shows that female rats escalate self-administration of entactogen psychostimulants under long-access conditions, leading to increased GABAergic inhibition and altered KOR signaling in the central nucleus of the amygdala.

DOI 10.1101/2021.09.24.461477

ratelectronic health records

𝕏 PostBluesky

NeurosciencebioRxivPreprintAug 18, 2017

Withdrawal-induced escalated oxycodone self-administration is mediated by kappa opioid receptor function

Jacques D. Nguyen, Dean Kirson, Michael Q. Steinman…·Michael A. Taffe

This study shows that extended oxycodone self-administration in rats leads to escalated drug use and dysregulation of KOR-mediated GABAergic signaling in the CeA, with distinct neuroadaptive effects compared to other drugs.

6 citations

ratexperimental assay

𝕏 PostBluesky