Marisa Roberto

This study shows that astrocyte-expressed STAT3 maintains glutamate transporter levels and promotes ethanol consumption in male mice.

This paper introduces RIPUP, a rapid protease-based workflow for histone PTM analysis, showing improved PTM coverage and quantitative accuracy using TMT labeling and complementary proteases.

This study identifies astrocyte reactivity in the central amygdala due to ethanol dependence through multi-omics analysis in mice, revealing adaptive and maladaptive changes in neuroimmune and cytoskeletal pathways.

This study identifies PSTN Crh neurons as a key driver of alcohol drinking escalation in dependence, showing their role shifts from inhibitory to stimulatory with dependence.

This study uses proteomics to compare CSF from alcohol-dependent and non-dependent mice, identifying molecular changes linked to BBB dysfunction and neuroinflammation.

This study identifies astrocyte-specific gene and pathway changes in the nucleus accumbens during alcohol dependence using RNA-Seq and TRAP, revealing distinct immune activation patterns compared to ethanol drinking.

This paper introduces a framework for interpreting single-cell proteomics data from patch-clamped neurons in acute brain slices, showing how retrieval quality affects proteomic outcomes.

This study shows that S-nitrosylation of CRTC1 impairs CREB-dependent gene expression in Alzheimer's disease models, leading to synaptic dysfunction and suggesting a therapeutic target.

This paper shows that adolescent voluntary alcohol exposure in mice and rats does not reliably increase adult alcohol consumption across multiple models and labs.

This study investigates whether ethanol's interaction with BK channel α subunit residue K361 mediates behavioral responses to alcohol in mice, finding no significant effects on ethanol-related behaviors or consumption.

This study shows that female rats escalate self-administration of entactogen psychostimulants under long-access conditions, leading to increased GABAergic inhibition and altered KOR signaling in the central nucleus of the amygdala.

This study investigates the role of CeA CRF neurons in alcohol dependence by using chemogenetics to assess their impact on behavior and neurotransmission during withdrawal.

This study shows that extended oxycodone self-administration in rats leads to escalated drug use and dysregulation of KOR-mediated GABAergic signaling in the CeA, with distinct neuroadaptive effects compared to other drugs.