Michael A. Taffe

This study compares the long-term effects of repeated heroin vapor inhalation during adolescence versus adulthood in female rats, finding lasting impacts on nociception and anxiety-like behavior, with more pronounced effects in adolescents.

This study examines the effects of 6-methyl nicotine (6-MN) vapor inhalation in rats, finding similar physiological and behavioral responses to nicotine.

This study finds that female Heterogeneous Stock rats self-administer opioids more frequently than males in various conditions, while males show greater sensitivity to heroin's anti-nociceptive effects.

This study investigates age-related differences in heroin's anti-nociceptive and rewarding effects in rats, finding diminished opioid reward in middle-aged males.

This study compares methamphetamine and α-PVP self-administration in male and female rats, finding sex differences in reinforcement and dose effects.

This study compares the physiological and behavioral effects of 6-methyl nicotine and nicotine in rats, finding similar effects on temperature, activity, and nociception.

This study compares the effects of nicotine inhalation and injection on locomotor activity and body temperature in male and female rats, finding sex-specific differences in response.

This study shows that THC increases oxycodone self-administration in rats, suggesting it enhances opioid reinforcement and addiction risk.

This study shows that female rats escalate self-administration of entactogen psychostimulants under long-access conditions, leading to increased GABAergic inhibition and altered KOR signaling in the central nucleus of the amygdala.

This study examines how oxycodone self-administration affects brain reward status in rats, finding that prolonged access leads to increased reward thresholds, which normalize during abstinence.

This study shows that Reelin deficiency exacerbates long-term behavioral issues in mice exposed to THC during adolescence, including impaired social behavior and increased novelty seeking.

This study investigates whether THC reduces oxycodone self-administration in rats under extended access conditions and finds additive antinociceptive effects when THC and oxycodone are combined.

This study investigates tolerance to THC's hypothermic and antinociceptive effects in rats through repeated vapor inhalation, finding gender differences in tolerance development.

This study shows that a vaccine against oxycodone reduces its reinforcing effects and prevents self-administration in rats.

The study investigates binge-like self-administration of α-PVP in female rats and finds that half exhibit high initial intake, with wheel activity devalued as a reward.

This study compares the locomotor and reinforcing effects of pentedrone, pentylone, and methylone in rats, finding that pentedrone and pentylone have greater abuse liability than methylone.

This study shows that extended oxycodone self-administration in rats leads to escalated drug use and dysregulation of KOR-mediated GABAergic signaling in the CeA, with distinct neuroadaptive effects compared to other drugs.

This study shows that wheel running in rats increases MDMA-induced hyperthermia and mortality rates, suggesting physical activity may heighten MDMA toxicity in humans.