Author

Michael R Brown

The University of Texas Health Science Center at Houston

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 2 Genetics· 1 Genomics· 1

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Research Focus:GWAS / association mapping· 4 Assay:GWAS summary statistics· 4 Organism:human· 4 Approach:statistical model· 4 Approach:Bayesian inference· 1 Research Focus:benchmarking· 1 Research Focus:fine-mapping· 1 Research Focus:polygenic risk· 1

Frequent Co-Authors

Aldi T. Kraja· 3 shared Amy R. BentleyiD· 3 shared Eric BoerwinkleiD· 3 shared Hugues AschardiD· 3 shared Karen SchwanderiD· 3 shared Mary Furlan FeitosaiD· 3 shared Paul S. de VriesiD· 3 shared Alanna C. MorrisoniD· 2 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Aldi T. Kraja

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Author profile →

4 papers

Recent·Most cited

A Large-Scale Genome-Wide Gene-Sleep Interaction Study in 732,564 Participants Identifies Lipid Loci Explaining Sleep-Associated Lipid Disturbances

Raymond Noordam, Wenyi Wang, Pavithra Nagarajan, Heming Wang, Michael R Brown, Amy R. Bentley, Qin Hui, Aldi T. Kraja, John L. Morrison, Jeffrey R. O’Connel, Songmi Lee, Karen Schwander, Traci M. Bartz, Lisa de las Fuentes, Mary Furlan Feitosa, , Rima Destya Triatin

This study identifies 17 genetic loci associated with sleep duration and lipid levels, offering potential druggable targets for dyslipidemia in individuals with sleep disturbances.

medRxiv · Sep 2, 2024 · PreprintGenetic & Genomic Medicine

Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants.

Krishna G. Aragam, Tao Jiang, Anuj Goel, Stavroula Kanoni, Brooke N. Wolford, Elle M. Weeks, Minxian Wang, George Hindy, Wei Zhou, Christopher Grace, Carolina Roselli, Nicholas Marston, Frederick Kamanu, Ida L. Surakka, Loreto Muñoz Venegas, , Adam S. Butterworth

A coronary artery disease GWAS of 181,522 cases among 1,165,690 participants yields 241 associations (54 new); an eight-predictor consensus nominates 185 candidate causal genes, 94 with ≥3 predictors.

medRxiv · May 24, 2021 · PreprintGenetic & Genomic Medicine✦ In-depth digest

Large-scale multivariate multi-ancestry Interaction analyses point towards different genetic mechanisms by population and exposure.

Vincent Laville, Timothy D. Majarian, Yun Ju Sung, Karen Schwander, Mary Furlan Feitosa, Daniel I. Chasman, Amy R. Bentley, Charles N. Rotimi, L. Adrienne Cupples, Paul S. de Vries, Michael R Brown, Alanna C. Morrison, Aldi T. Kraja, Michael A. Province, C. Charles Gu, , on behalf of the CHARGE Gene-Lifestyle Interactions Working Group

The paper analyzes gene-environment interaction effects across multiple ancestries and traits, identifying population-specific genetic mechanisms and methodological biases in GxE studies.

bioRxiv · Jan 17, 2020 · PreprintGenetics

Multi-ancestry analysis of gene-sleep interactions in 126,926 individuals identifies multiple novel blood lipid loci that contribute to our understanding of sleep-associated adverse blood lipid profile

Raymond Noordam, Maxime M. Bos, Heming Wang, Thomas W. Winkler, Amy R. Bentley, Tuomas O. Kilpeläinen, Paul S. de Vries, Yun Ju Sung, Karen Schwander, Brian E. Cade, Alisa Knodle Manning, Hugues Aschard, Michael R Brown, Han Chen, Nora Franceschini, , André Gerardus Uitterlinden

The paper identifies 49 novel blood lipid loci associated with gene-sleep interactions in 126,926 individuals across 5 ancestry groups, with gene-short-sleep interactions explaining 4.25% of triglyceride variance.

bioRxiv · Feb 25, 2019 · PreprintGenomics