Charles N. Rotimi

The paper identifies a novel genetic locus OSBPL11 associated with vitamin D levels and cardiometabolic health in African populations through genome-wide analysis.

The paper develops gene expression prediction models for asthma-related tissues in African-ancestry populations and identifies 17 candidate causal asthma genes using transcriptome-wide association study.

The paper analyzes genetic diversity in the All of Us Research Program, showing that self-identified race and ethnicity groups exhibit continuous genetic variation rather than discrete clusters, with implications for genetic association studies.

This study identifies the ACE2 pathway as a critical regulator of thermogenesis and energy metabolism, showing its role in improving metabolic parameters and browning of white adipose tissue.

This paper conducts a GWAS in Africans to identify novel lipid loci and finds 23 novel associations, with some replicating in African Americans and additional loci emerging from meta-analysis.

This study evaluates genetic risk scores for cardiometabolic traits in sub-Saharan Africans, African Americans, and European Americans, finding significantly lower predictive utility in sub-Saharan Africans.

This study evaluates if African American or multi-ethnic polygenic risk scores improve type 2 diabetes prediction in continental Africans, finding that African American-derived scores are more predictive.

This paper compares alignment-based and assembly-based variant calling in Africans, finding that assembly-based methods detect more clinically relevant variants and reveal biases in existing reference databases.

The paper analyzes gene-environment interaction effects across multiple ancestries and traits, identifying population-specific genetic mechanisms and methodological biases in GxE studies.

The paper identifies a novel type 2 diabetes locus, ZRANB3, in sub-Saharan Africans and shows its potential role in beta cell proliferation through zebrafish studies.

The paper uses whole genome sequence data to trace the origin of the sickle allele to the Holocene Wet Phase, showing a single origin and simplifying haplotype classification.

This study identifies novel asthma susceptibility loci in individuals of African ancestry through genome-wide association analysis and admixture mapping.