Spectinamide MBX-4888A exhibits favorable lesion and tissue distribution and promotes treatment shortening in advanced murine models of tuberculosis
Allison A. Bauman, Jansy Passiflora Sarathy, Firat Kaya, Lisa M. Massoudi, Michael S. Scherman, Courtney Hastings, Jiuyu Liu, Min Xie, Elizabeth J. Brooks, Michelle E. Ramey, Isabelle L. Jones, Noalani D. Benedict, Madelyn R. Maclaughlin, Jake A. Miller-Dawson, Samanthi L. Waidyarachchi, , Gregory T. Robertson
This study shows that MBX-4888A, a spectinamide, shortens tuberculosis treatment in murine models by improving tissue distribution and working well with rifampin and pyrazinamide.
Antimicrobial Agents and Chemotherapy · Sep 30, 2024Peer-reviewedMicrobiology