Comprehensive preclinical reevaluation of PaBQU and DBQU regimens identifies lesional liability in hard-to-treat forms of tuberculosis
Nicholas D. Walter, Lisa M. Massoudi, Allison Bauman, Noalani D. Benedict, Nathan Peroutka‐Bigus, Michelle E. Ramey, Reem Al Mubarak, Samantha Pauly, Firat Kaya, Linda Chaba, Matthew D. Zimmerman, Debra Flood, David Hermann, Khisimusi Mdluli, David L. Holtzman, , Gregory T. Robertson
This study reevaluates PaBQU and DBQU regimens in mouse models, finding they have lesional liability in complex lesions, which may explain their failure in a human trial.
bioRxiv · Sep 17, 2026 · PreprintMicrobiology