KRAS inhibition is an effective therapy for appendiceal adenocarcinoma
Saikat Chowdhury, Ichiaki Ito, Vinay K. Pattalachinti, Abdelrahman M.G. Yousef, Mahmoud Yousef, Sacha El Khoury, Nicholas J. Hornstein, Ashlee Nichole Seldomridge, David S. Hong, Micheal J. Overman, Melissa W. Taggart, Wai Chin Foo, Beth Helmink, Keith F. Fournier, John Paul Shen
This study evaluates KRAS inhibitors in appendiceal adenocarcinoma models and patients, showing efficacy in reducing tumor growth and suggesting potential resistance mechanisms.
Journal of Hematology & Oncology · Jul 2, 2026Peer-reviewedCancer Biology