Nicholas J. Hornstein

This study identifies KDM5D on the Y chromosome as a suppressor of CD8+ T cell antitumor immunity in males, linking it to TCR and cholesterol-exhaustion programs.

This study evaluates KRAS inhibitors in appendiceal adenocarcinoma models and patients, showing efficacy in reducing tumor growth and suggesting potential resistance mechanisms.

This study creates a spatial proteomic atlas of SBA tumor-immune microenvironment, revealing cell interactions and immune checkpoint patterns linked to patient survival and therapy.

This study introduces riboPLATE-seq, a method for generating paired libraries of ribosome-associated and total mRNA, and demonstrates its use in detecting translational changes caused by kinase inhibitors.

This study uses ribosome profiling to show that Fmr1 loss in mice affects translation elongation and initiation, with reduced pausing and altered mRNA binding.