Author

Michelle Leiser

University of Cambridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Liz KoganiD· 2 shared Mihkel ÖrdiD· 2 shared Pau CreixelliD· 2 shared Amelia BarclayiD· 1 shared Devin A. Bradburn· 1 shared Mardo KõivomägiiD· 1 shared Mingxuan JiangiD· 1 shared Norman E. DaveyiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 27 mutual co-author links

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2 shared papersMolecular Biology

Liz KoganORCID

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Author profile →

2 papers

Recent·Most cited

HCF1 orchestrates O-GlcNAcylation and affinity-dependent transcription through extended molecular determinants and register-shifted binding

Mihkel Örd, Sydney A. Porto, Amelia Barclay, Mingxuan Jiang, Liz Kogan, Michelle Leiser, Pau Creixell

This study identifies new HCF1 binding partners and molecular determinants, revealing how HCF1 regulates transcription and O-GlcNAcylation through affinity-dependent mechanisms.

bioRxiv · Mar 20, 2026 · PreprintMolecular Biology

Uncovering cancer dependencies in peptide-interacting protein pockets

Mihkel Örd, Liz Kogan, Devin A. Bradburn, Michelle Leiser, Mardo Kõivomägi, Norman E. Davey, Pau Creixell

The paper screens peptide-binding pockets across cancer cell lines to identify therapeutic vulnerabilities and dependencies, finding that peptide inhibition can reveal hidden dependencies and enhance drug efficacy.

bioRxiv · Mar 15, 2026 · PreprintCancer Biology