Pau Creixell

This study identifies new HCF1 binding partners and molecular determinants, revealing how HCF1 regulates transcription and O-GlcNAcylation through affinity-dependent mechanisms.

The paper screens peptide-binding pockets across cancer cell lines to identify therapeutic vulnerabilities and dependencies, finding that peptide inhibition can reveal hidden dependencies and enhance drug efficacy.

This paper shows that pervanadate induces oxidation, which activates SRC kinases by disrupting autoinhibition and altering SH2 domain phosphopeptide binding, revealing a redox-dependent mechanism for SRC activation.

The paper identifies molecular determinants for phosphotyrosine recognition in tyrosine kinases and shows their roles in tumor promotion and suppression.

This study identifies FANCL and Ube2T as HR-promoting factors at DSBs and shows they regulate CtIP recruitment and end-resection for homologous recombination.

The paper identifies a dual histone modification (H3K9me3 and H3K27me3) that specifies Rhino binding to a subset of piRNA source loci in Drosophila germ cells, independent of Kipferl.

This study reveals a hierarchical organization in the kinase domain that enables regulatory plasticity through distinct functional units.

The paper identifies and engineers phosphorylation sites on kinases to rewiring cell signaling through allosteric regulation.