The stress-protectant molecule trehalose mediates fluconazole tolerance in Candida glabrata
Qingjuan Zhu, Stefanie Wijnants, Regina Feil, Wouter Van Genechten, Rudy Vergauwen, Odessa Van Goethem, John Edward Lunn, Mieke Van Ende, Patrick Van Dijck
This study identifies trehalose as a mediator of fluconazole tolerance in C. glabrata by altering sterol composition, showing that trehalose deficiency reduces drug tolerance.
Antimicrobial Agents and Chemotherapy · Jan 24, 2025Peer-reviewedMicrobiology