Age-related decline of synaptic plasticity is regulated by neuro-androgen and neuro-estrogen in normal aging of hippocampus
Suguru Kawato, Yasushi Hojo, Mari Ogiue‐Ikeda, Mika Soma, Minoru Saito, Jonghyuk Kim, Arisa Munetomo, Shimpei Higo, Hirotaka Ishii, Asami Kato, Hideo Mukai, Ayako Hiragushi, Takuji Shirasawa, Takahiko Shimizu, Shigeo Horie
The paper shows that age-related decline in hippocampal dendritic spine density in male rats is linked to decreased neuro-androgen levels and partially offset by estrogen.
bioRxiv · Aug 17, 2025 · PreprintNeuroscience