Author

Hirotaka Ishii

The University of TokyoORCID 0000-0003-2044-316XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Mari Ogiue‐Ikeda· 2 shared Mika Soma· 2 shared Minoru SaitoiD· 2 shared Shigeo HorieiD· 2 shared Shimpei HigoiD· 2 shared Suguru KawatoiD· 2 shared Arisa Munetomo· 1 shared Asami Kato· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersNeuroscience

Mari Ogiue‐Ikeda

Mutual co-authors in cluster

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3 papers

Recent·Most cited

PhysiologybioRxivPreprintSep 3, 2026

Age-associated erosion of organ-specific endothelial programs compromises tissue function and resilience

Haruko Watanabe‐Takano, Tomohiro Ishii, Tomohisa Hayakawa…·Shigetomo Fukuhara

This study identifies age-related erosion of organ-specific endothelial programs and links it to tissue dysfunction across multiple organs.

DOI 10.64898/2026.07.02.735775

𝕏 PostBluesky

NeurosciencebioRxivPreprintAug 17, 2025

Age-related decline of synaptic plasticity is regulated by neuro-androgen and neuro-estrogen in normal aging of hippocampus

Suguru Kawato, Yasushi Hojo, Mari Ogiue‐Ikeda…·Shigeo Horie

The paper shows that age-related decline in hippocampal dendritic spine density in male rats is linked to decreased neuro-androgen levels and partially offset by estrogen.

1 citation

ratstatistical model

𝕏 PostBluesky

NeurosciencebioRxivPreprintDec 24, 2024

Inhibition of PDE5 induces rapid non-genomic increase in hippocampal dendritic spines via specific kinases

Mika Soma, Mari Ogiue‐Ikeda, Shigeo Horie…·Suguru Kawato

The paper shows that tadalafil increases hippocampal dendritic spines rapidly and non-genomically through PKG and GSK-3 inhibition.

DOI 10.1101/2024.12.24.630287

𝕏 PostBluesky