Shigeo Horie

The paper shows that age-related decline in hippocampal dendritic spine density in male rats is linked to decreased neuro-androgen levels and partially offset by estrogen.

The paper discusses methodological improvements for measuring neuro-estrogen and neuro-androgen concentrations and dendritic spine density in rat hippocampus to address inconsistencies and variability in results.

The paper shows that tadalafil increases hippocampal dendritic spines rapidly and non-genomically through PKG and GSK-3 inhibition.