Viral load-driven systemic immune exhaustion is an enabler of antibody breadth in HIV infection
Izumi de los Rios Kobara, Uma M. Mangalanathan, Soneida DeLine-Caballero, Kassandra Pinedo, Mikayla A. Stabile, Camilo A. Espinosa, Hannah L. Itell, Vrasha Chohan, Raymond Scott McClelland, Kishorchandra Mandaliya, Julie M. Overbaugh, Catherine A. Blish
The paper identifies viral load-driven immune exhaustion as a factor enabling antibody breadth in HIV infection by analyzing longitudinal data from a Kenyan cohort.
bioRxiv · Jun 17, 2026 · PreprintImmunology