Catherine A. Blish

This study shows that engineered NK cells with a CD4-based CAR delay HIV rebound and alter the reservoir's composition in humanized mice.

This study shows that juvenile influenza infection in mice impairs myelin development and leads to lasting cognitive and behavioral issues, which can be mitigated by inhibiting the chemokine receptor CCR3.

The paper identifies viral load-driven immune exhaustion as a factor enabling antibody breadth in HIV infection by analyzing longitudinal data from a Kenyan cohort.

The paper identifies a novel SARS-CoV-2-derived circular RNA, circ7b8N, which modulates host gene expression and is detectable in clinical samples, suggesting a role in host-pathogen interactions.

This study develops an immune organoid model to study HIV infection, treatment, rebound, and intervention in human lymphoid tissues.

The paper shows that NK cell activation during SARS-CoV-2 infection correlates with reduced neutralization breadth of antibodies.

This study compares NK cell receptor expression in ZIKV and dengue-infected individuals, finding persistent phenotypic changes in ZIKV infection and virus-specific differences in NK cell activation.

This study identifies NKp30:B7-H6 and NKG2D:MICB/ULBP2 as receptor-ligand pairs that contribute to NK cell recognition of HIV-infected cells.

The paper presents a multimodal epigenome atlas of human immune cells exposed to viral and chemical agents, revealing epigenetic changes in transcription factor binding sites and cytokine networks.

This study identifies cytokines that enhance influenza vaccine antibody responses in human organoids and mice, showing their potential as adjuvants to improve vaccine efficacy.

scMetaIntegrator provides a meta-analysis approach for paired scRNA-seq data, improving robustness and reducing false positives by accounting for biological replicates and cell variability.

The paper examines transcriptional changes in adipose tissue from subacute COVID-19 and Long COVID patients, finding no persistent viral RNA but significant transcriptional remodeling in subacute cases and no consistent gene expression differences in Long COVID.

This study compares immune profiles of children living with HIV who started antiretroviral treatment at different times and durations, finding distinct immune differences between early and delayed treatment groups.

This study identifies sex-specific immune correlates of Long COVID development, persistence, and resolution using multi-omic analyses of blood samples from patients with and without Long COVID.

The paper integrates multi-omic data to identify genetic and microbiome factors associated with severe COVID-19, independent of ancestry and social factors.

The paper uses CRISPR screens to identify mucins as key host factors that restrict SARS-CoV-2 infection in human lung cells.

This paper identifies activated interstitial macrophages as a key target of SARS-CoV-2 infection in human lung tissue, showing their role in viral takeover, inflammation, and fibrosis.

The paper uses CRISPRa screening and real-world data to identify KCNA6 as a neuronal entry factor for SARS-CoV-2 and shows dalfampridine can suppress viral entry.

Weighted-nearest neighbor (WNN) analysis in Seurat v4 learns per-cell modality weights to define cell states, enabling a 228-antibody human PBMC CITE-seq reference for RNA-only query mapping.

CytoGLMM provides statistical methods for differential analysis of flow and mass cytometry data, improving robustness to marker correlations and patient heterogeneity.

This study examines B cell clonal expansion and convergent antibody responses in SARS-CoV-2 patients, identifying shared features with SARS-CoV.

This study shows human NK cells distinguish influenza A strains through cytokine priming and receptor-ligand signaling, with pH1N1 inducing stronger IFN-gamma responses than H3N2.