Tracking the embryonic stem cell transition from ground state pluripotency
Tüzer Kalkan, Nelly N. Olova, Mila Roode, Carla Mulas, Heather J Lee, Isabelle R. E. Nett, Hendrik Marks, Rachael V. Walker, Hendrik G. Stunnenberg, Kathryn Susan Lilley, Jennifer Nichols, Wolf Reik, Paul Bertone, Austin G Smith
The paper tracks the transition of mouse embryonic stem cells from ground state pluripotency to a formative phase, showing acute exit from naive status and transcriptome changes similar to early post-implantation epiblast.
Development · Feb 7, 2017Peer-reviewedDevelopmental Biology