Hendrik Marks

This study generates pro-regenerative macrophages from hESCs to treat OA, showing they reduce inflammation and restore cartilage via TNFAIP3 signaling.

The paper identifies a lipid metabolism-induced checkpoint during the exit of naïve pluripotency that ensures genome integrity through telomere regulation.

This study investigates DNA methylation changes in SetDB1-deficient mouse ESCs, revealing its role in silencing retrotransposons and imprinted regions through coordination with H3K9me3.

The paper shows that pluripotent mouse embryonic stem cells silence MDA5 to avoid endogenous dsRNA recognition, preventing IFN activation and ensuring normal development.

The paper identifies gene regulatory differences between primary human hepatocytes and organoid-derived hepatocytes using integrative omics analysis.

This paper introduces a microfluidic platform for standardized, sensitive ChIP-Seq on low-input samples, enabling high-throughput and reproducible epigenetic profiling.

The paper investigates how PRC2 sub-complexes recruit to target genes in mESCs, revealing mutual reinforcement and feedback mechanisms between PRC2.1, PRC2.2, and PRC1.

This study shows that P53 regulates G1-phase progression in ground state ESCs by controlling RB expression, and its inactivation leads to loss of RB and uncontrolled proliferation.

The paper tracks the transition of mouse embryonic stem cells from ground state pluripotency to a formative phase, showing acute exit from naive status and transcriptome changes similar to early post-implantation epiblast.