Harnessing the FBXW7 somatic mutant R465C for targeted protein degradation
Ananya A. Basu, Chenlu Zhang, Milad Rouhimoghadam, Anil Vasudevan, Justin M. Reitsma, Xiaoyu Zhang
This study shows that the FBXW7 R465C somatic mutant can be used for targeted protein degradation via heterobifunctional compounds.
Journal of the American Chemical Society · Feb 6, 2025Peer-reviewedBiochemistry