Anil Vasudevan

The paper introduces AgnoTACs, bifunctional molecules that enable proteome-wide discovery of degradable proteins, identifying over 50 previously untargeted proteins.

This paper introduces an in-cell method to evaluate E3 ligases for targeted protein degradation by conjugating neo-substrates via click chemistry.

This study shows that the FBXW7 R465C somatic mutant can be used for targeted protein degradation via heterobifunctional compounds.

The paper derives physicochemical rules for small molecule binding to RNA using extensive binding data and applies them to validate known RNA-targeting compounds and drugs.