A Guanine-quadruplex located on the negative strand of the hepatitis C virus facilitates efficient genomic RNA synthesis
Simmone D’souza, Scott Tersteeg, Maulik D. Badmalia, Annie Y. Chen, Milan S. Heck, Guido van Marle, Jennifer A. Corcoran, Carla S. Coffin, Trushar R. Patel
This paper identifies a conserved G4 structure in the HCV negative strand 3 UTR that is essential for efficient RNA synthesis by facilitating NS3 helicase recruitment and NS5B polymerase access.
bioRxiv · May 14, 2025 · PreprintBiophysics