Author

Maulik D. Badmalia

University of LethbridgeORCID 0000-0002-3384-6550Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Assay:proteomics· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

Trushar R. PateliD· 2 shared Ankush SinghaliD· 1 shared Annie Y. CheniD· 1 shared Arpit Kumar GuptaiD· 1 shared Ashish· 1 shared Calvin J. GordoniD· 1 shared Carla S. CoffiniD· 1 shared Carlos Rivera-LópeziD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersBiophysics

Trushar R. PatelORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cleavage region organizes the structural architecture of the B2 SINE ribozyme

Ankush Singhal, Tyler Mrozowich, Carlos Rivera-López, Susmitnarayan Chaudhury, Lilei Xu, Rodrigo Aguilar, Maulik D. Badmalia, Jeannie T. Lee, Trushar R. Patel, Karissa Y. Sanbonmatsu

The paper determines the structural ensemble-to-function relations of the B2 SINE ribozyme using RNA chemical probing, X-ray scattering, and modeling, showing cleavage site dependency on its structure and function.

Communications Biology · Mar 23, 2026Peer-reviewedBiophysics

A Guanine-quadruplex located on the negative strand of the hepatitis C virus facilitates efficient genomic RNA synthesis

Simmone D’souza, Scott Tersteeg, Maulik D. Badmalia, Annie Y. Chen, Milan S. Heck, Guido van Marle, Jennifer A. Corcoran, Carla S. Coffin, Trushar R. Patel

This paper identifies a conserved G4 structure in the HCV negative strand 3 UTR that is essential for efficient RNA synthesis by facilitating NS3 helicase recruitment and NS5B polymerase access.

bioRxiv · May 14, 2025 · PreprintBiophysics

Single-molecule assay reveals the impact of composition, RNA duplex, and inhibitors on the binding dynamics of SARS-CoV-2 polymerase complex

Terri C. Lovell, Heidi A. F. Dewling, Cynthia X. Li, Hery W. Lee, Calvin J. Gordon, Dana Kocíncová, Maulik D. Badmalia, Egor P. Tchesnokov, Matthias Götte, Gonzalo Cosa

This study uses a single-molecule assay to analyze the binding dynamics of SARS-CoV-2 polymerase complex subunits with RNA, revealing differences in binding stability between co-expressed and reconstituted complexes and the effects of inhibitors.

bioRxiv · Jan 10, 2025 · PreprintBiophysics

VISUALIZING GAUSSIAN-CHAIN LIKE STRUCTURAL MODELS OF HUMAN alpha-SYNUCLEIN IN MONOMERIC PRE-FIBRILLAR STATE: SOLUTION SAXS DATA AND MODELING ANALYSIS

Madhumita Dey, Arpit Kumar Gupta, Maulik D. Badmalia, Ashish, Deepak Sharma

The paper uses SAXS data and modeling to analyze the conformational ensemble of monomeric pre-fibrillar human alpha-synuclein, concluding a shifting equilibrium of curved models with low alpha-helical content.

International Journal of Biological Macromolecules · Dec 12, 2024Peer-reviewedBiophysics