BiophysicsbioRxivPreprint
A Guanine-quadruplex located on the negative strand of the hepatitis C virus facilitates efficient genomic RNA synthesis
Simmone D’souza, Scott Tersteeg, Maulik D. Badmalia…·Trushar R. Patel
This paper identifies a conserved G4 structure in the HCV negative strand 3 UTR that is essential for efficient RNA synthesis by facilitating NS3 helicase recruitment and NS5B polymerase access.
DOI 10.1101/2025.05.14.654041