Candida glabrata maintains two Hap1 homologs, Zcf27 andZcf4, for distinct roles in ergosterol gene regulation to mediate sterol homeostasis under azole and hypoxic conditions
Debasmita Saha, Justin B. Gregor, Smriti Hoda, Katharine E. Eastman, Mindy Navarrete, Jennifer H. Wisecaver, Scott D. Briggs
This study identifies Zcf27 and Zcf4 as distinct regulators of ergosterol gene expression in C. glabrata, showing their roles in azole resistance and hypoxic adaptation.
bioRxiv · Jun 20, 2024 · PreprintGenetics