Debasmita Saha

Candida glabrata maintains two Hap1 homologs, Zcf27 andZcf4, for distinct roles in ergosterol gene regulation to mediate sterol homeostasis under azole and hypoxic conditions

This study identifies Zcf27 and Zcf4 as distinct regulators of ergosterol gene expression in C. glabrata, showing their roles in azole resistance and hypoxic adaptation.

xpanding the toolkit for genetic manipulation and discovery in Candida species using a CRISPR ribonucleoprotein-based approach

This paper expands genetic manipulation tools in Candida species using CRISPR-Cas9 RNP with new drug resistance cassettes, enabling efficient gene deletions and epitope tagging in multiple fungal pathogens.

Set1-mediated histone H3K4 methylation is required for azole induction of the ergosterol biosynthesis genes and antifungal drug resistance in Candida glabrata.

This study shows that Set1-mediated histone H3K4 methylation is essential for azole-induced expression of ergosterol biosynthesis genes and antifungal drug resistance in C. glabrata.