Stepwise Ligand Capture Primes PKR for Activation and RNA Discrimination
Chong Han, Chen Li, Yi-Feng Xu, Ming Rao, Shao-Qing Zhang, Ling‐Ling Chen, Jiaquan Liu
This study reveals how PKR's dsRBDs work together to enable selective RNA recognition and activation through a two-step ligand sampling mechanism.
Proceedings of the National Academy of Sciences · Sep 30, 2026Peer-reviewedBiophysics