BiophysicsProceedings of the National Academy of SciencesPeer-reviewed
Stepwise Ligand Capture Primes PKR for Activation and RNA Discrimination
Chong Han, Chen Li, Yi-Feng Xu…·Jiaquan Liu
This study reveals how PKR's dsRBDs work together to enable selective RNA recognition and activation through a two-step ligand sampling mechanism.
DOI 10.1073/pnas.2605220123