Targeting protein tyrosine phosphatase non-receptor type 2 with a novel inhibitor for AML therapy
Wenbin Kuang, Jinxin Jiang, Xiao Wang, Dawei Wang, Minghui Ji, Yasheng Zhu, Kai Yuan, Jiayu Ding, Wenmu Wang, Mingge Song, Wenjian Min, Fei Huang, Liping Wang, Wanjian Gu, Haiping Hao, , Peng Yang
This study identifies PTPN2 as a therapeutic target in AML, discovers a selective inhibitor K73, and demonstrates its efficacy in reducing AML burden in vitro and in vivo.
bioRxiv · May 7, 2024 · PreprintCancer Biology