VDJdive and ECLIPSE enhance single-cell TCR sequencing analysis through the probabilistic resolution of ambiguous clonotypes
Ethan C Burns, Mercedeh Javanbakht Movassagh, Jill F. Lundell, Mingzhi Ye, Zhaochen Ye, Giacomo Oliveira, Rishabh Rout, Miya B. Hugaboom, Kelly Street, David A. Braun
VDJdive and ECLIPSE resolve ambiguous clonotypes in scTCR-seq by improving chain pairing and clone size estimation, enhancing clonal tracking across conditions.
bioRxiv · Feb 20, 2026 · PreprintImmunology