Cheng Luo

GRAFT predicts drug responses across cell types without direct measurements by transferring genetic perturbation data to chemical perturbations.

This study develops CIRCmap to profile cell-surface and intracellular RNAs, identifies cancer-associated csRNAs, and demonstrates oligonucleotide-drug conjugates targeting these RNAs show broad antitumor activity.

This study identifies a compound that inhibits RhoA activation by stabilizing its GDP state, reducing myocardial remodeling and fibrosis in heart failure models.

This paper introduces LJY-3-60, a molecular glue that induces CRBN homodimerization and autodegradation, providing a tool for controlled protein degradation.

This study shows that FMRP phosphorylation regulates neuronal translation via YTHDF1, revealing a mechanism for FXS pathology and suggesting YTHDF1 as a therapeutic target.

The paper introduces gcaPDA, a diploid assembler that uses haploid gamete cells to resolve haplotypes, and demonstrates its effectiveness on a complex maize genome.