Site-Dependent Decoupling of Drug-Biomarker Associations in Clear Cell Renal Cell Carcinoma Revealed by Functional Profiling of Patient-Derived Cell Models
Michaela Feodoroff, Tamara J. Luck, Romika Kumari, Minttu Polso, Patrick Penttilä, Minna Malmstedt, Piia Mikkonen, Lauren J. Gerber, Ruusu‐Maaria Merivirta, Mariliina Arjama, Erika Romppanen, Matilda Roos-Mattila, Pauliina Kallio, Swapnil Potdar, Mikaela Grönholm, , Vilja M. Pietiäinen
The paper identifies site-dependent drug-biomarker associations in ccRCC using patient-derived models and multi-omic data, revealing discrepancies between genomic predictions and functional drug responses.
bioRxiv · Jul 9, 2026 · PreprintCancer Biology