Author

Petrus Järvinen

University of HelsinkiORCID 0000-0002-3751-4609Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:drug response / drug discovery· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Tuomas K. MirttiiD· 4 shared Olli KallioniemiiD· 3 shared Antti Sakari RannikkoiD· 2 shared Erika Romppanen· 2 shared Minna Malmstedt· 2 shared Minttu PolsoiD· 2 shared Panu JaakkolaiD· 2 shared Piia MikkoneniD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

Tuomas K. MirttiORCID

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Author profile →

4 papers

Recent·Most cited

Site-Dependent Decoupling of Drug-Biomarker Associations in Clear Cell Renal Cell Carcinoma Revealed by Functional Profiling of Patient-Derived Cell Models

Michaela Feodoroff, Tamara J. Luck, Romika Kumari, Minttu Polso, Patrick Penttilä, Minna Malmstedt, Piia Mikkonen, Lauren J. Gerber, Ruusu‐Maaria Merivirta, Mariliina Arjama, Erika Romppanen, Matilda Roos-Mattila, Pauliina Kallio, Swapnil Potdar, Mikaela Grönholm, , Vilja M. Pietiäinen

The paper identifies site-dependent drug-biomarker associations in ccRCC using patient-derived models and multi-omic data, revealing discrepancies between genomic predictions and functional drug responses.

bioRxiv · Jul 9, 2026 · PreprintCancer Biology

Pathway-centric multi-omics and functional precision medicine reveal shared drug vulnerabilities in heterogeneous adult Wilms tumor

Minttu Polso, Romika Kumari, Tamara J. Luck, Piia Mikkonen, Katja Välimäki, Ruusu‐Maaria Merivirta, Minna Malmstedt, Johanna Lehtonen, Erika Romppanen, Sara Kuusela, Antti Hassinen, Janna Saarela, Teijo S. Pellinen, Panu Jaakkola, Pia Suonpää, , Vilja M. Pietiäinen

This study identifies shared drug vulnerabilities in adult Wilms tumor through multi-omics and functional assays, showing pathway-level dependencies predict drug responses better than single-gene biomarkers.

bioRxiv · Jun 25, 2026 · PreprintCancer Biology

Patient-derived tumor explant models of tumor immune microenvironment reveal distinct and reproducible immunotherapy responses

Rita Turpin, Karita Peltonen, Jenna H. Rannikko, Ruixian Liu, Anita N. Kumari, Daniel Nicorici, Moon Hee Lee, Minna Mutka, Panu E. Kovanen, Laura Niinikoski, Tuomo J Meretoja, Johanna Mattson, Petrus Järvinen, Kanerva Lahdensuo, Riikka Järvinen, , Juha T. Klefström

The paper evaluates immunomodulatory drug responses in patient-derived tumor explant models of breast and renal cancer, finding reproducible gene expression and cytokine changes across models.

OncoImmunology · Feb 17, 2025Peer-reviewedImmunology

Fibroblast Activation Protein Defines an Aggressive, Immunosuppressive EMT-associated Tumor Subtype in Highly Inflamed Localized Clear Cell Renal Cell Carcinoma

Teijo S. Pellinen, Lassi Luomala, Kalle Mattila, Annabrita Hemmes, Katja E. Välimäki, Oscar E. Brück, Lassi Paavolainen, Elisa Kankkunen, Harry Nísen, Petrus Järvinen, Leticia Castillon, Sakari Vanharanta, Paula Vainio, Olli Kallioniemi, Panu Jaakkola, Tuomas K. Mirtti

The paper identifies FAP-expressing EMT-associated cancer cells in highly inflamed localized ccRCC as an aggressive, immunosuppressive subtype linked to poor prognosis and metastasis.

bioRxiv · Oct 27, 2024 · PreprintCancer Biology